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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DOK2
All Species:
11.82
Human Site:
S140
Identified Species:
28.89
UniProt:
O60496
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60496
NP_003965.2
412
45379
S140
M
E
E
N
E
L
Y
S
S
A
V
T
V
G
P
Chimpanzee
Pan troglodytes
XP_519640
412
45373
S140
M
E
E
N
E
L
Y
S
S
A
V
T
V
G
P
Rhesus Macaque
Macaca mulatta
XP_001114039
206
22378
Dog
Lupus familis
XP_543259
411
45419
Y139
R
M
E
E
N
E
L
Y
S
S
T
T
A
G
L
Cat
Felis silvestris
Mouse
Mus musculus
O70469
412
45504
Y142
C
M
E
E
N
E
L
Y
S
S
S
T
T
G
L
Rat
Rattus norvegicus
Q4QQV2
480
52151
S147
M
L
E
N
S
L
Y
S
P
T
W
E
G
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506018
432
47473
S143
L
E
D
A
K
A
G
S
L
S
P
T
A
L
P
Chicken
Gallus gallus
A3R064
426
47148
N137
Q
P
I
P
M
E
E
N
C
L
Y
S
S
W
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_998253
575
63920
N139
Q
E
L
Q
M
A
E
N
L
I
Y
Y
S
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792985
602
64705
D144
E
G
D
A
E
L
Q
D
N
L
L
Y
D
S
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
46.5
84.2
N.A.
74.5
34.5
N.A.
64.8
33.7
N.A.
33
N.A.
N.A.
N.A.
N.A.
23.9
Protein Similarity:
100
99.5
47.3
87.8
N.A.
79.3
45.2
N.A.
74
48.1
N.A.
44.7
N.A.
N.A.
N.A.
N.A.
35.8
P-Site Identity:
100
100
0
26.6
N.A.
26.6
40
N.A.
26.6
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
0
33.3
N.A.
33.3
40
N.A.
53.3
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
0
20
0
0
0
20
0
0
20
0
0
% A
% Cys:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% C
% Asp:
0
0
20
0
0
0
0
10
0
0
0
0
10
0
0
% D
% Glu:
10
40
50
20
30
30
20
0
0
0
0
10
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
10
0
0
0
0
0
10
40
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
10
0
0
40
20
0
20
20
10
0
0
10
20
% L
% Met:
30
20
0
0
20
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
30
20
0
0
20
10
0
0
0
0
0
0
% N
% Pro:
0
10
0
10
0
0
0
0
10
0
10
0
0
0
30
% P
% Gln:
20
0
0
10
0
0
10
0
0
0
0
0
0
0
20
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
10
0
0
40
40
30
10
10
20
20
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
10
50
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
20
0
20
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% W
% Tyr:
0
0
0
0
0
0
30
20
0
0
20
20
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _